Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder

نویسندگان

  • Conny Kopp-Scheinpflug
  • Bruce L. Tempel
چکیده

The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Auditory processing skills in brainstem level of autistic children: A Review Study

Aims: Autism is a pervasive developmental disorder. Deficit in sensory functions is one of the characteristics of people with autism, and usually these people show abnormality in processing and correct interpretation of auditory information. Also people with Autism show problems in communicating with others. This review article deals with the accurate understanding of Auditory processing skills...

متن کامل

Auditory Temporal Processing Abilities in Early Azari-Persian Bilinguals

Introduction: Auditory temporal resolution and auditory temporal ordering are two major components of the auditory temporal processing abilities that contribute to speech perception and language development. Auditory temporal resolution and auditory temporal ordering can be evaluated by gap-in-noise (GIN) and pitch-pattern-sequence (PPS) tests, respectively. In this survey, the effect of biling...

متن کامل

سایکوآکوستیک و درک گفتار در افراد مبتلا به نوروپاتی شنوایی و افراد طبیعی

Background: The main result of hearing impairment is reduction of speech perception. Patient with auditory neuropathy can hear but they can not understand. Their difficulties have been traced to timing related deficits, revealing the importance of the neural encoding of timing cues for understanding speech. Objective: In the present study psychoacoustic perception (minimal noticeable differen...

متن کامل

Comparing auditory sustained attention in children with auditory processing disorder and normal children

Introduction: Auditory processing disorder (APD) is a type of abnormal perceptual processing of auditory information within the central auditory nervous system that could be influenced by cognitive factors, such as attention. Attention is one of most important cognitive functions in the development of learning in children, so it is important to recognize and evaluate a variety of attention defi...

متن کامل

Auditory Lateralization Ability in Children with (Central) Auditory Processing Disorder

Objectives: The aim of the present study was to assess the auditory lateralization ability in children with (central) auditory processing disorder. Methods: Participants were divided in two groups: 15 children with Central Auditory Processing Disorder (8-10 years) and 80 normal children (8-11 years) from both genders with pure-tone air-conduction thresholds better than 20 dB HL bilaterally a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Hearing Research

دوره 330  شماره 

صفحات  -

تاریخ انتشار 2015